In vivo CRISPR animal models and services

High Efficiency Genome Editing Service for Drug Discovery


From genome editing to disease models and PK-PD-efficacy studies



In Vivo CRISPR Platform for Rare Disease


  • Well-established in vivo gene editing platform in rodent
  • Generation of genetically engineered animal models (GEAM) for drug discovery in rare disease
  • 30+ knockin and knockout mouse lines generated last year



Efficacy Evaluation and MoA Research Platform


  • Well-established in vitro, ex vivo and in vivo bioassay platforms
  • Multiple routes for drug administration, animal and tissue manipulation and histopathology



Knockout Services


  • CRISPR/CAS9 based knockout in mouse, rat
  • ES cell based knockout in mouse



Knockin Services


  • CRISPR/CAS9 based knockin in mouse, rat
  • ES cell based knockin in mouse



Humanization Services


  • In situ replace mouse gene with matched human exons or introns
  • Express human cDNA under the control of mouse promoter



Transgenic Services


  • Random integration into genome
  • Targeted transgene into Rosa26 or other site



Genotyping and Phenotyping Services


  • Analyze the genotype of mice and cells by PCR, Southern Blot or NGS
  • Characterization of disease mouse models



Other Services


  • In vitro fertilization
  • Embryo and sperm cryopreservation



Compliance and Accreditations


  • AAALAC accredited facility
  • OECD – received a statement of GLP compliance from the Belgium regulatory authorities
  • Chinese SFDA – received certificate of GLP compliance
  • WuXi has conducted IND and NDA enabling studies for submission to the US FDA



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